临床前研究的质量是诊所成功翻译新药的关键。这种质量的重要推动力是一个健康，精心管理，精确的动物殖民地。为了实现这一目标，需要致力和经验，成功统治于最先进的设施，技术和殖民地管理实践的专业知识，以及全面的健康和遗传监测协议。研究人员如何确保灵活地访问可靠的这些高质量型号的供应？好吧，有一个艺术给它。
The critical role of contract breeding services
By taking advantage of contract breeding services like those offered at Envigo, research organizations benefit from a highly skilled workforce. The primary role of these professionals is to develop and maintain models that can provide researchers with accurate and conclusive answers to their research questions. As such, Envigo’s team has perfected a range of innovative strategies and techniques that overcome the traditional hurdles (including genetic drift, changes in health status, and regulatory changes) to maintaining a consistent and reliable model. Below, we highlight some of the actions Envigo takes to ensure research continuity throughout a preclinical program.
Strategic cohort supply
Choosing the right animal for a study is not the only factor researchers need to consider when developing their protocols. The timing and availability of a model represents an additional major challenge. By working closely with our research partners to understand their research objectives and timelines, Envigo can:
+通过合同育种隔离器实现对殖民地尺寸的精确调整
+预料supply needsto avoid superfluous populations, without risking an underpowered sample size.
In addition, speed congenics can be used to accelerate generational breeding in animal models.
Rigorous, full spectrum health monitoring programs
At the core of Envigo’sFull Spectrum health monitoring是一系列全面的服务，允许研究人员测试，报告，解释和快速响应。这包括：
+On-site biosecurity assessment
+定制测试轮廓设计使用非牺牲面板技术(NSP) wherever possible (where samples are collected directly from the animals and/or their environments, without need for euthanasia)
+100% validated testing to deliver a clear picture of colony health (including serology, bacteriology, parasitology, and pathology)
+Scheduled reporting and expert support for interpretation.
Importantly, when these strategies identify a biosecurity concern, Envigo can deploy a range of services to help colonies recover quickly. Notably, Envigo’s冷冻保存of sperm and embryos (preservation of the normal function of cells via a reduction in temperature so that biochemical reactions cannot take place)andrederivation(involving isolation of a pre-implantation stage embryo for transfer to a clean recipient female)服务确保了潜在的生物安全问题，确保了研究连续性. Additionally, speed derivation can be used to yield a larger cohort size under the same health conditions.
Genetic integrity assurance program
Alongside health monitoring, it is also necessary for researchers to maintain the genetic integrity of their research models. Envigo’s three-tiered approach is the most comprehensive and transparent program in the industry.
+The program involves comprehensive and frequent genetic monitoring to detect contamination or bottlenecking using single nucleotide polymorphism analysis (SNP), thereby combining speed, efficiency, and accuracy.
+Envigo employs industry-standard breeding schemes alongside operational procedures that act to keep genetic divergence to a minimum. Inbred strains are maintained via a pyramid mating system that reduces the likelihood of cumulative drift, and heterogeneity of outbred stocks is achieved using a rotational system that ensures only unrelated animals are mated together.
+Genetic drift – via spontaneous mutation, bottlenecking, migration, or epigenetic processes – is managed using a colony refreshing program, thereby optimizing genetic consistency within and between sites.
In short, Envigo employs game-changing techniques in the art of contract breeding, so you can continue with the science. To speak with a specialist about your contract breeding needs, pleasecontact us.