积极：见解

Pre-clinical models underpin some of the most exciting discoveries in neuroscience. For example, over the last three decades, animal models have enabled scientists to describe how we navigate our environment and uncover the mechanisms by which this ability is lost in Alzheimer's disease. These models are fundamental tools in characterizing the neural pathways that control coordinated movement, driving discoveries of pathological changes in those pathways that lead to the motor symptoms of Parkinson's disease.

研究中的定制抗体有很多用途，从开发治疗方法以其使用体外测定。抗体的生产是一种技术上要求耗费耗时的过程，并且为选择具有强大轨道记录的供应商至关重要。在这里，我们与Envigo的Rook Khajenouri - 我们的抗体制作专家 - 关于在研究中使用抗体时考虑的一些关键因素。B0B体育平台下载Rook还讨论了Envigo这样的研究组织在生产过程的每个阶段提供了高技能专家，从初始决策到缩放生产。B0B体育平台下载

The quality of preclinical research is key to the successful translation of new drugs to the clinic. An important driver of this quality is a healthy, meticulously managed, and accurately characterized animal colony. To achieve this requires dedication and experience, and success depends critically on state-of-the-art facilities, expertise in technologies and colony management practices, as well as comprehensive health and genetic monitoring protocols. How can researchers ensure flexible access to a reliable supply of these high-quality models? Well, there’s an art to it.

手术改性的动物模型在生物医学研究中发挥着关键作用，允许研究人员模仿人体状况的结构和功能性。然而，它只具有高度一致的标准化模型，研究人员可以自信他们的结果是可靠和可重复的。然而，维持完成精确的外科手术所需的技术技能是个人研究实验室的昂贵和耗时。因此，较差的研究团队越来越识别合同研究服务可以添加的价值。bob软件苹果怎么下载

It is well established that personalized medicine can overcome some limitations of a one-size-fits-all approach to healthcare. In research and practice, personalized medicine is being increasingly utilized. For example, it is playing an increased role in efficacy studies for biomarker-driven therapies and informs treatment.

然而，对于该领域进一步发展，高于临床前模型的发展是必不可少的，以评估新的靶向疗法并增加临床中可动作突变的范围。一种这样的模型，有助于桥接临床前研究和临床，是患者衍生的异种移植物（PDX） - 其中来自患者肿瘤的组织植入免疫缺陷或人源化小鼠。

在研究中使用PDX模型意味着诊所中所见的突变可以从研究计划的最早阶段进行考虑到发现管道，在临床前设置。Andrew Brown，Envigo的全球产品经理解释了这种方法如何改变癌症治B0B体育平台下载疗的未来：

“PDX模型允许我们从诊所向后工作，以便开发阶段可以针对患者中所见的突变。我们可以继续筛选其他患者的这些突变，提供有机会与治疗有机会与个人配对被瞄准了他们的肿瘤的真正代表性。“

Effective colony management ensures reproducible research outcomes and adherence to the principles of the 3Rs. Cryopreservation and rederivation services are highly effective tools for meeting these standards but are not yet broadly used.最近的研究已经透露，许多实验室专业人员都不知道冷冻保存和重新激活的有效殖民地管理的好处，这可能解释了各种设施的这些服务的可变吸收。

现在,研究diffic后恢复ulties posed by COVID-19, researchers are keenly aware of the need to consider proactive disaster-mitigation strategies within their colony management plans. With this additional focus in mind, cryopreservation and rederivation services are uniquely placed to bolster efficiency, embed 3R principles, and ensure research continuity in the face of unseen circumstances.

由于Covid-19导致的研究优先事项的转变需要在生物医学领域进行快速调整。这种反应的速度和有效性支持我们目前对病毒的科学了解，最终将导致症状治疗和预防疫苗。

In particular, animal research is critical in the global search for a treatment or vaccine for COVID-19. Rodent models are advancing our understanding of the virus itself, and research in non-human primates can确保潜在疗法的安全性曲线, before they proceed to human trials.

然而，动物研究组织正在经历与任何其他行业相同的Covid-19相关并发症。对于那些提供本研究所需工具和服务的人来说，确保科学家继续获得所需品的突出关注。

Below, we highlight some of the ways the industry has adapted since the pandemic began:

为什么非人类的缺点是科学界的严重问题？

非人类灵长类动物（NHPS）对于新药物应用的临床发展途径至关重要，但NHP供应商目前正在努力满足全球需求前所未有的浪涌。

一种国家健康研究所(NIH) survey of grants awarded between 2013 and 2017 revealed that nearly half of NIH-funded investigators reported difficulty in obtaining sufficient numbers of NHPs or related services for their research. The implications of this include critical delays in study initiation and widespread requests for grant extensions. These are driven by stretched timelines and increased costs, unforeseen when grant amounts were originally requested.

保护研究资金在全球范围内的所有学科竞争中越来越困难，以获得批准。例如，国家健康研究院（NIH）每年投资近420亿美元的医学研究。百分之八十的逐步研究。这是大约50,000名竞争性拨款到全球2500多所大学，医学院和其他研究机构的300,000多名研究人员。

niH.granted 3,413 awardsto 167 of those research institutions last year. It's the largest, single source of funding for biomedical research in the world. Yet, those numbers suggest investigators have a less than seven percent chance of receiving NIH approval. Here are four tips to help scientists succeed in securing grants and other funding:

实验室大鼠和老鼠已经使用了几十年来使艾滋病毒抗逆转录病毒对流感疫苗进行了很大的医学进步。但是一直是一个有趣的辩论，这是更有用的动物模型 - 大鼠或小鼠。

With the current devastating emergence of the coronavirus pathogen, flexible research models have never been more important. Let’s take a closer look at the story behind the debate to see if 2020 will indeed be the year of the lab rat.