Positive : Insights

TheR2G2.^®mouse has the potential to help you break new ground in investigational cancer therapies. In two recent studies, this model tolerated standard of care chemotherapy and estrogen supplementation well in terms of overall survival and changes in body weight. Here are five reasons why this mouse model could serve as an excellent host for your preclinical human tumor xenograft studies.

The selection of your animal model for toxicity and carcinogenicity testing plays an essential role in the accuracy of your study findings. Our researchers recently completed a two-year study of 130 male and 130 femaleEnvigo RccHan®:WIST (Wistar Han®)老鼠并将它们与其他争吵进行比较rats (e.g., Sprague-Dawley®, Fischer 344). Here, we share the results of the study.

The results provided insights on how Wistar Han provided numerous advantages, such as smaller body size, higher rates of survival and lower tumor/lesion incidence, as compared toCRL:CD®(SD) (CD)大鼠模型是前两年的研究的主题。

You’ve spent years building the ideal colony for your study – and have invested even more resources into maintaining it for future usage. Imagine that after investing time and money developing and maintaining your colony, it could become redundant due to a natural disaster, microbial contamination, or facility failure. And, given the increased use of immunodeficient models and sensitive microbiota research projects, along with the cost and complexity of model breeding,冷冻保存should be woven into the fabric of each and every research project.

动物导管提供有价值的工具，以通过多种方式降低实验性变化。它允许一致的剂量和一致的血液取样，同时将压力与动物及其处理者相同。但并非所有导管类型都是平等的。了解不同的选项将有助于您为您的学习选择最佳的啮齿动物外科手术模型。

最大化2018年及以后的抗体的研究，诊断或治疗使用

It was a busy year for Envigo’s custom antibodies team in 2017. As another year came to an end, we collated a round-up of the top 8 insightful materials that were published by the team throughout last year. We hope these will help you maximize your research, diagnostic or therapeutic use of antibodies in 2018 and beyond.

Wishing you a prosperous 2018!

正在进行努力推进研究，诊断和治疗产品

很难想象一个没有抗体的世界。除了他们在动物中抗击疾病的自然能力之外，科学界广泛应用于科研和开发工具。抗体，多克隆（PAB）和单克隆（MAB）, are well established and versatile reagent tools for the study of a wide variety of biological functions, 3D structure analysis, metabolic pathways studies, in vivo imaging, cell modulation, and quantification of a host of analytes. They are also used astherapeutic drugsand are amongst the biggest selling therapeutics making a significant difference to patients’ lives.

Antigen selection and preparation

抗原的最佳选择和制备对于获得高质量抗体至关重要在多克隆和单克隆抗体生产中。虽然抗原选择和准备的重要性并不立即对该领域的一些人显而易见，但Envigo的经验表明这是一个批判考虑因素。B0B体育平台下载

The production of antibodies for use in research and development and in medicine has a long history. Although there is no doubt that the use抗体对我们对生物学的基本了解作出了重大贡献, they have also been singled out as a major factor in the poor reproducibility of many biology-based studies.

Selecting the right model and rodent strain for your oncology studies can maximize the chances of success. However, there is an ever-increasing portfolio of available models and strains that may perform better than existing ones and may be more optimal for specific study purposes.

增加的调查人员正在寻求从现有的啮齿动物菌株向另一个啮齿动物菌株进行桥接，以便其肿瘤介的临床前疗效和药理学研究。与切换菌株相关的短期障碍可能会出现复杂和令人生畏，但另一个应变实际上可能是肿瘤学突出前程序成功的关键。

一定要了解如何从切换到新的肿瘤啮齿动物菌株中受益。

创建高效细胞系需要始于伟大的照顾细胞系开发.Envigo’s Rook Khajenouri and Richard Druckerunderstand the challenges客户面临整个过程。他们最近讨论了一些常见的产量问题，并提供了确保的解决方案consistent and reliableresults that enhancedantibody production.