CLOSE×

    Brain

    Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby L, Santarelli L, Beck S, Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult.
    Nature 416:396-400

    Holmen SL, Williams BO. 2005. Essential role for Ras signaling in glioblastoma maintenance.
    癌症Res 65:8250-8255

    Gastrointestinal

    Barraclough J, Hodgkinson C, Hogg A, Dive C, Welman A. 2007. Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.
    Neoplasia 9:745-754

    Bell EL, Emerling BM, Ricoult SJ, Guarente L. 2011. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production.
    Oncogene 30:2986-2996

    Cawthorne C, Swindell R, Stratford IJ, Dive C, Welman A. 2007. Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model.
    J Biomol Tech 18:120-123

    Martin-Fernandez C, Bales J, Hodgkinson C, Welman A, Welham MJ, Dive C, Morrow CJ. 2009. Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.
    Mol Cancer Res 7:955-965

    Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. 2010. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice.
    Cell Cycle 9:3039-3045

    Welman A, Cawthorne C, Ponce-Perez L, Barraclough J, Danson S, Murray S, Cummings J, Allen TD, Dive C. 2006. Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.
    Neoplasia 8:905-916

    Kidney

    Reidy KJ,Villegas G,Teichman J,Veron D,Shen W,Zhen W,Jimenez J,Thomas D,Tufro A. 2009. Semaphorin3a调节肾小球发育过程中的内皮细胞数和多粒细胞分化。
    Development 136:3979-3989

    Liver

    Weng Y, Fang C, Turesky RJ, Behr M, Kaminsky LS, Ding X. 2007. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
    Cancer Res 67:7825-7832

    Mammary

    Daniel J, Coulter J, Woo JH, Wilsbach K, Gabrielson E. 2011. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.
    Proc Natl Acad Sci U S A 108:5384-5389

    Darrasse-Jeze G, Bergot AS, Durgeau A, Billiard F, Salomon BL, Cohen JL, Bellier B, Podsypanina K, Klatzmann D. 2009. Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice.
    J Clin Invest 119:2648-2662

    Parsa S, Ramasamy SK, De Langhe S, Gupte VV, Haigh JJ, Medina D, Bellusci S. 2008. Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling.
    DEV BIOL 317:121-131

    Podsypanina K,Politi K,Beverly LJ,Varmus He。2008. MYC和突变体KRA诱导的小鼠乳腺癌肿瘤维持和肿瘤复发中的癌症合作。
    Proc Natl Acad Sci U S A 105:5242-5247

    肌肉

    Ward AJ, Rimer M, Killian JM, Dowling JJ, Cooper TA. 2010. CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1.
    Hum Mol Genet 19:3614-3622

    Pancreas

    杜YC,Klimstra DS,Varmus H. 2009.在β细胞中的Pymt激活诱导不可逆增生,但在胰腺祖细胞中激活时依赖于依赖性腺体细胞癌。
    PLoS One 4:e6932

    Respiratory

    Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M. 2009. Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.
    J Clin Invest 119:636-649

    El-Hashash啊,艾尔·阿拉姆D, Turcatel G, Bellusci年代,Warburton D. 2011. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung.
    DEV BIOL 350:112-126

    Le A,Zielinski R,He C,Crow Mt,Biswal S,Tuder RM,Becker PM。2009.肺上皮神经素-1缺失增强了烟雾诱导的肺气肿的发育。
    Am J Respir Crit Care Med 180:396-406

    Lian X, Qin Y, Hossain SA, Yang L, White A, Xu H, Shipley JM, Li T, Senior RM, Du H, Yan C. 2005. Overexpression of Stat3C in pulmonary epithelium protects against hyperoxic lung injury.
    J Immunol 174:7250-7256

    Manwani N, Gagnon S, Post M, Joza S, Muglia L, Cornejo S, Kaplan F, Sweezey NB. 2010. Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor.
    Am J Respir Cell Mol Biol 43:599-606

    Motz GT, Eppert BL, Wortham BW, Amos-Kroohs RM, Flury JL, Wesselkamper SC, Borchers MT. 2010. Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.
    J Immunol 184:4460-4469

    Mucenski Ml,Wert Se,Nation JM,Loudy De,Huelsken J,Birchmeier W,Morrisey EE,Whitsett Ja。2003.在肺部形态发生期间,β-Catenin需要规范近端/远端细胞命运。
    J Biol Chem 278:40231-40238

    Perl AK, Riethmacher D, Whitsett JA. 2011. Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis.
    Am J Respir Crit Care Med 183:511-521

    Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. 2006. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.
    Genes Dev 20:1496-1510

    Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. 2011. A rapid and scalable system for studying gene function in mice using conditional RNA interference. |
    Cell 145:145-158

    Regales L, Balak MN, Gong Y, Politi K, Sawai A, Le C, Koutcher JA, Solit DB, Rosen N, Zakowski MF, Pao W. 2007. Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
    PLoS One 2:e810

    Reynolds PR, Mucenski ML, Le Cras TD, Nichols WC, Whitsett JA. 2004. Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.
    J Biol Chem 279:37124-37132

    Saini Y, Harkema JR, LaPres JJ. 2008. HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.
    J Biol Chem 283:33650-33657

    Saini Y, Greenwood KK, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.
    Toxicol Sci 116:673-681

    Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ. 2010. Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.
    AM J Physiol肺细胞Mol Physiol 298:L139-147

    Sala FG, Del Moral PM, Tiozzo C, Alam DA, Warburton D, Grikscheit T, Veltmaat JM, Bellusci S. 2011. FGF10 controls the patterning of the tracheal cartilage rings via Shh.
    Development 138:273-282

    田Y,周R,Rehg Je,Jackowski S. 2007.磷光籽细胞苷1转移酶α在肺部发育中的作用。
    Mol Cell Biol 27:975-982

    Volckaert T,莳萝E,Campbell A,Tioozo C,Majka S,Bellusci S,De Langhe Sp。2011.蛋白苔藓平滑肌在损伤后在小鼠肺部构成气道上皮干细胞Niche。
    J Clin Invest 121:4409-4419

    Weng Y, Fang C, Turesky RJ, Behr M, Kaminsky LS, Ding X. 2007. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
    Cancer Res 67:7825-7832

    Wesselkamper SC, Eppert BL, Motz GT, Lau GW, Hassett DJ, Borchers MT. 2008. NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection.
    J Immunol 181:5481-5489

    Dental

    Parsa S,Kuremoto K,Seidel K,Tabatabai R,Mackenzie B,Yamaza T,Akiyama K,Branch J,Koh CJ,Al Alam D,Klein OD,Bellusci S. 2010. FGFR2B的信号传导控制成人小鼠门牙的再生能力。
    Development 137:3743-3752

    Whole Body

    Diaz-Rodriguez E, Sotillo R, Schvartzman JM, Benezra R. 2008. Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.
    Proc Natl Acad Sci U S A 105:16719-16724

    Sotillo R,Hernando E,Diaz-Rodriguez E,Teruya-Feldstein J,Cordon-Cardo C,Lowe SW,Benezra R. 2007. Mad2过表达促进小鼠中的短倍性和肿瘤发生。
    Cancer Cell 11:9-23

    Xenograft

    Barraclough J, Hodgkinson C, Hogg A, Dive C, Welman A. 2007. Increases in c-Yes expression level and activity promote motility but not proliferation of human colorectal carcinoma cells.
    Neoplasia 9:745-754

    Bell EL, Emerling BM, Ricoult SJ, Guarente L. 2011. SirT3 suppresses hypoxia inducible factor 1alpha and tumor growth by inhibiting mitochondrial ROS production.
    Oncogene 30:2986-2996

    Cawthorne C, Swindell R, Stratford IJ, Dive C, Welman A. 2007. Comparison of doxycycline delivery methods for Tet-inducible gene expression in a subcutaneous xenograft model.
    J Biomol Tech 18:120-123

    Daniel J, Coulter J, Woo JH, Wilsbach K, Gabrielson E. 2011. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.
    Proc Natl Acad Sci U S A 108:5384-5389

    Martin-Fernandez C, Bales J, Hodgkinson C, Welman A, Welham MJ, Dive C, Morrow CJ. 2009. Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs.
    Mol Cancer Res 7:955-965

    Parsa S, Ramasamy SK, De Langhe S, Gupte VV, Haigh JJ, Medina D, Bellusci S. 2008. Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling.
    DEV BIOL 317:121-131

    Welman A, Cawthorne C, Ponce-Perez L, Barraclough J, Danson S, Murray S, Cummings J, Allen TD, Dive C. 2006. Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.
    Neoplasia 8:905-916

    Ask a nutritionist live chat

    Ask anutritionist

    在线聊天在线聊天
    Teklad diets selector app

    Teklad dietselector

    Selector appSelector app
    Brad<br>Gien, Global Head of Surgery

    MeetBrad
    Gien

    Global Head of Surgery

    View ProfileView Profile
    洞察, Keep up-to-date with the latest industry thinking and scientific insights

    Scientific洞察

    Keep up-to-date with the latest industry thinking and scientific insights

    Explore todayExplore today