• Background strain: Sprague Dawley
• Biallelic 726 bp deletion within Abcc2 gene
• Decreased transport of endogenous glutathione
• Homozygous knockout rats display total loss of protein via Western blot
• Hyperbilirubinemia

Availability:冷冻保存作为杂合胚胎
Zygosity:Homozygous

Homozygous Mrp2 null rats display compromised biliary excretion and hyperbilirubinemia. This results in accumulation of glutathione-conjugated drugs in the liver.

Mrp2 is expressed in the liver and functions in biliary transport. The gene's substrates include anticancer compounds such as vinblastine, enabling it to confer multiple drug resistance to tumor cells. This model is useful for forumational, efficacy, tissue distribution, and DMPK assays