• Homozygotes exhibit multiple phenotypes involving intestinal, respiratory, and reproductive phenotypes (see Description).

Availability:Cryopreserved as a mix of Heterozygous & WT embryos
Zygosity:Heterozygous

CFTR knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (CFTR), resulting in loss of protein expression.

CFTR knockout rats lack CFTR protein as demonstrated by western blot. CFTR KO rats develop intestinal obstructions shortly after weaning leading to weight loss and mortality. CFTR KO rats also exhibit decreased trachea circumference as well as submucosal gland volume. Stored nasal mucus volume is increased. Abnormal dentition is observed, and the vas deferens is absent in male CFTR knockout rats.