• Macrophages from homozygous knockout rats demonstrate less Th1 response with less IFN-? secretion after simulation with PMAHomozygous knockout rats show decreased bone mass
• Homozygous knockout rats show elevated serum alkaline phosphotase levels
• Background Strain: Sprague-Dawley

Availability: Cryopreserved as heterozygous embryos
Zygosity: Heterozygous

T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN. Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn's disease, colitis, cancer metastasis, autoimmune disorders and inflammation.