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    很难想象一个没有单克隆抗体（mAb）的世界，作为他们自己的试剂和治疗剂;他们在进步基础研究，诊断和产品开发方面发挥了重要作用。

    定制抗原特异性小鼠单克隆抗体的生产是耗时和技术要求的过程。使用Envigo目的繁殖模型，在美国或英国的最先进的设施中进行抗体的生产。B0B体育平台下载我们培训的人员为您提供各种抗体服务的无与伦比的专业知识。

    In vivo(ascites) production

    为一种经济的方法,Envigo BioproductsB0B体育平台下载ers monoclonal antibody production as ascites in our FDA registered cGMP compliant facility. Our ready access to large numbers of high quality, genetically defined adventitious virus-free mice and rats ensures a rapid turn-around time at a competitive price. We can also help maximize your yield time through our innovative Optimization Program.

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    Service Description 细胞系 生产类型 Capacity Advantages
    Optimization program Different doses tested Ascites available can be evaluated before use; Small to large run sizes Hybridomas, NSO and SP2/0 Balb/c, Nude, SCID, and other species 小于大于大型群体（10mg-100g） Determine optimal cell dose; Allows maximal yield; Verifies specifications; Saves time
    Research ascites production (non-cGMP) 当不需要CGMP时;独特的服务;与cgm相同的阶段 Hybridomas, NSO and SP2/0 Balb/c, Nude, SCID, and other species Small to large Scale (10mg-100g) 没有地图测试要求;周转时间更快;自定义协议;减少成本
    cGMP production 诊断/治疗用途;丰富的质量;程序经过完全测试 Hybridomas, NSO and SP2/0 Balb/c, Nude, SCID, and other species Small to large Scale (10mg-100g) Aaalac认可的CGMP兼容;优化生产;大型动物库存;完整的文件

    体外单克隆抗体生产

    B0B体育平台下载Envigo Bioproducts具有在体外生产单克隆或分泌蛋白质的专业知识。我们在我们的创新组织培养袋和中空纤维生产单元中，我们具有生产10mg-300g的研究或CGMP抗体或其他分泌的蛋白质。我们提供各种媒体选项，如RPMI，DMEM，IMDM，无血清，无蛋白质或其他自定义媒体配方。

    Service Description 细胞系 生产类型 Capacity Advantages
    Small scale production 对于早期可行性，克隆选择和媒体优化，较小研究的成本效益良好 杂交瘤（CHO，293，PERC.6和分泌的蛋白质） Tissue; Culture Bag; Hollow Fiber; Bioreactor Up to 1 gram per project 减少成本Yield~20-150mg per 1 L bag; Quick turn-around; Excellent oxygen transport
    Large scale production Flexible and easy scale up; Larger scale research and cGMP runs 杂交瘤（CHO，293，PERC.6和分泌的蛋白质） 空心;纤维;生物反应器 10mg-300g per project 最大环境控制;可重复的制造过程;减少外来蛋白质;高度集中的产品

    杂交瘤发展

    B0B体育平台下载Envigo科学家，兽医和技术人员拥有40多年的经验，改善了我们从各种肽和蛋白质开发单克隆抗体的方法。虽然我们的程序定义得很好，但我们需要的时候是灵活的。

    Envigo Bioproducts' hybridoma development program is a flexible, interactive, and cost effective multi-phased service. We will work closely with you to design a program that will meet your requirements. Our custom development options include providing up to three, five, or ten clones, or as many as you require. As our client, you retain all rights to any clones that are produced. Once the clones are developed, we can scale them up as tissue culture supernatant.

    Service Requirements Project outcomes
    阶段I：免疫 Immunize mice with antigen; Boost/test by ELISA or alternate method; Additional boost(s) if needed; Pre-fusion boost Move mice with best titers as fusion candidates; Immunizing multiple mice increases success
    Stage II: Fusion/screen and select 融合骨髓瘤细胞系;在哈特中间屏幕/选择中生长细胞;屏幕 屏幕所有最初板;扩大良好的井和ELISA测试;设置最多30个克隆的阳性;保持冻结备份以备将来测试
    第三阶段：克隆/冻结股票 第一次克隆;最终克隆;选择非HT要求;冷冻股票和小抗体放大 Clone by limiting dilution method; Test clones by ELISA; Several cloning cycles; Final clones expanded and small amount of antibody produced

    Customer experiences

    R539-1When you work with Envigo, you can be confident that through our experience, we ensure consistent and reliable products for research and industry.

    了解Engigo如何帮助公B0B体育平台下载司提供定制抗体服务，click hereto read more.

    触摸 - 联系我们的抗体和生物制作队

    At Envigo, we are dedicated to helping you secure the potential of your product by providing you with a comprehensive selection of research animals. Our experts are ready to assist you.

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    Viktoria <br> Hyddmark，博士，高级科学家

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    海德博士博士

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    Joe<br>Warren, Senior Scientist

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    沃伦

    高级科学家

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