对流增强的抗miR传递具有良好的耐受性，保持了抗miR的稳定性，并导致有效的靶去抑制：概念证明（Halle，2016）

利用胶质瘤原位异种移植模型（Envigo的裸鼠），研究者试图评估对流增强输送（CED）抗miR抑制miR的效率和安全性。在体内，作者通过CEB0B体育平台下载D将抗let-7a投与原位T87来源的肿瘤中，靶向一个验证良好的mIR（let-7a）。输注1个月后，切除肿瘤，检测hook 2靶基因高迁移率组（HMGA2）的肿瘤mRNA水平。作者发现抗-miR治疗的动物肿瘤中的HMGA2水平被显著抑制，抗-miR的完整性在泵中被保留，没有动物表现出抗-miR治疗引起的严重不良反应的迹象。因此，作者得出结论，这些初步的概念验证数据应该通过使用CED来传递关键的致癌mir来进一步推进。

Read the full reference document atwww.ncbi.nlm.nih.gov/pubmed/26428358

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Proton MR Spectroscopy and Diffusion MR Imaging Monitoring to Predict Tumor Response to Interstitial Photodynamic Therapy for Glioblastoma (Toussaint 2017)

In a recent study, investigators used male athymic nude rats (Hsd:RH-Foxn1rnu) (athymic nude rat from Envigo) with intracranial glioblastoma xenografts to assess tumor response to interstitial photodynamic therapy (iPDT), a site-specific tumor treatment technique that uses laser fibers inserted directly into the depth of the tumor. Rats were injected with AGuIX^®nanoparticles (which encapsulate the photodynamic therapy (PDT) and imaging agents) prior to iPDT treatment. Tumor response to iPDT was monitored using non-invasive imaging techniques. Specifically, Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) were used to follow-up on post-treatment effects over time. Overall, the authors found that conventional MRI, T2 star (T2*), Diffusion Weighted Imaging (DWI), and MRS were all able to extract relevant profiles on tissue cytoarchitectural alterations, local vascular disruption, and metabolic information on brain tumor biology. Together, these markers helped achieve earlier assessment of tumor response. Notably, after only one day post-iPDT, DWI and MRS successfully identified several promising markers, such as Apparent Diffusion Coefficient (ADC) values, lipids, choline and myo-inositol levels, which permitted the researchers to distinguish iPDT responders from non-responders.

Read the full reference document atwww.ncbi.nlm.nih.gov/pubmed/28255341

Further related studies can be found in ourcell line references

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